Topics in Population Genetics and Genomics
Instructor: Alon Keinan (ak735[at]cornell.edu)
Biological Statistics and Computational Biology (BSCB), 102C Weill Hall
To subscribe: Send a mail to email@example.com with the word 'join' in the body of the message
Where: Weill Hall 121
When: Wednesdays from 1:30 to 2:30 pm
BTRY 6890 is graduate seminar on population genetics and comparative genomics. It takes the form of a Journal Club, where each week students, post-doc and faculty meet to discuss a short scientific publication. During these meetings, one participant of the group gives a brief overview of a pre-defined paper and then the group discusses the methods and the results.
A list of papers to pick for discussion will be presented during the first meeting.
These papers are carefully chosen to be representative of two main topics: Balancing Selection and Natural selection and Coalescent Theory. Each topic will be focused on during a few consecutive weeks.
Having several weeks around the same topic will permit to: 1) acquire a broad understanding of the topics of interest, 2) in-depth study of current scientific issues and challenges related to these topics, 3) develop a critical approach to scientific results.
This is a 1 credit course (S/U). The requirements for taking it for credit are:
1. Lead the discussion for one of the weeks of the class.
2. Attendance and participation in discussions.
Schedule of presentations:
|Elodie Gazave||A limited role for balancing selection. (Astana S et al.) 2004||Click Here|
|Balancing Selection and Its Effects on Sequences in Nearby Genome Regions. (Charlesworth D) 2006||Click Here|
|02/01/2012||Kaixiong Ye||The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations.
(Charlesworth B, Nordborg M, Charlesworth D, 1997)
|02/08/2012||Haley Hunter-Zinck||Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. (Solberg OD et al. 2008)||Click Here|
|02/15/2012||Lenore Pipes||Consequences of population structure on genes under balancing selection. (Muirhead CA 2001)||Click Here|
|02/22/2012||Diana Chang||The genealogy of sequences containing multiple sites subject to strong selection in a subdivided population. (Nordborg M, Innan H) 2003||Click Here|
|02/29/2012||Pavitra Muralidhar||Targets of balancing selection in the human genome. (Andres A et al. 2009)||Click Here|
|03/07/2012||Lenore Pipes||Scan of human genome reveal no new loci under ancient balancing selection. (Bubb et al. 2006)||Click Here|
|03/14/2012||Alberto Romero||Heterozygote advantage as a natural consequence of adaptation in diploids. (Sellis D et al. 2011)||Click Here|
|03/21/2012||Spring Break … Spring Break … Spring Break|
|03/28/2012||Colette Picard||The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. (Pritchard JK, Pickrell JK, Coop G. 2010)||Click Here|
|04/04/2012||Jishnu Das||The genealogy of samples in models with selection. (Neuhauser C & Krone SM 1997)||Click Here|
|04/11/2012||Alexis Mychajliw||The effect of hitch-hiking on neutral genealogies. (Barton N 1998)||Click Here|
|04/18/2012||Ilan Gronau||A method to correct for the effects of purifying selection on genealogical inference. (O'Fallon BD 2010)||Click Here|
|04/25/2012||SangChul & Matt||The Structure of Genealogies in the Presence of Purifying Selection: A “Fitness-Class Coalescent”. (Walczak AM et al. 2011)||Click Here|
|05/02/2012||Jaaved Mohammed||The Drosophila melanogaster Genetic Reference Panel. (Mackay TF et al. 2012)||Click Here|