Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing

TitleAnalyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing
Publication TypeJournal Article
Year of Publication2011
AuthorsGottipati S, Arbiza L, Siepel A, Clark AG, Keinan A
JournalNat. Genet.
Volume43
Pagination741–743
ISSN1546-1718
KeywordsChromosome Mapping, Chromosomes, Demography, Female, Genes, Genetic, Genetic Variation, Genetics, Genome, Human, Humans, Population, Selection, X, X-Linked
Abstract

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.

URLhttp://keinanlab.cb.bscb.cornell.edu/sites/default/files/papers/gottipati_etal_2011_analysesofxlinked_natgenet.pdf
DOI10.1038/ng.877