Alon Keinan studies how human genetic variation has arisen from evolutionary history. His research focuses on elucidating the history of modern human populations and on developing computational methods for searching for genes important in human biology. With a background in computer science and statistics, Keinan develops theoretical tools and applies them to genomic data sets, bridging theoretical population genetics and empirical studies.
L. Ma, A. G. Clark, and
Gene-Based Testing of Interactions in Association Studies of Quantitative Traits.
PLoS Genetics, 9, e1003321 (2013).
A. Keinan and A. G. Clark.
Recent explosive human population growth has resulted in an excess of rare genetic variants.
Science, 336, 740-743 (2012). ( Supplementary information)
L. Ma, A. Brautbar, E. Boerwingle, C. F. Sing, A. G. Clark, and
Knowledge-driven analysis identifies a gene-gene interaction affecting high-density lipoprotein cholesterol levels in multi-ethnic populations.
PLoS Genetics, 8, e1002714 (2012).
D. Chang and
Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation.
PLoS Computational Biology, 8, e1002600 (2012).
L. Arbiza, E. Zhong, and
NRE: A tool for exploring neutral loci in the human genome.
BMC Bioinformatics, 13, 301 (2012).
( NRE webserver)
L. Ma, C. M. Ballantyne, J. W. Belmont,
A. Keinan, and A. Brautbar.
Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia.
Journal of Lipid Research, 53, 2425-2428 (2012).
S. Gottipati, L. Arbiza, A. Siepel, A. G. Clark, and
Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.
Nature Genetics, 43, 741-743 (2011). ( Supplementary information)
Y. Y. Waldman, T. Tuller,
A. Keinan, and E. Ruppin. Selection for translation efficiency on synonymous polymorphisms in recent human evolution.
Genome Biology and Evolution, 3, 749-761 (2011).
The International HapMap3 Consortium.
Integrating common and rare genetic variation in diverse human populations.
Nature, 467, 52-58 (2010). ( Supplementary information)
A. Keinan and D. Reich.
Human population differentiation is strongly correlated with local recombination rate.
PLoS Genetics, 6, e1000886 (2010).
A. Keinan, J. C. Mullikin, N. Patterson, and D. Reich.
Accelerated genetic drift on chromosome X during the human dispersal out of Africa.
Nature Genetics, 41, 66-70 (2009). ( News and Views; Supplementary information; Data)
A. Keinan, J. C. Mullikin, N. Patterson, and D.
of the human allele frequency spectrum demonstrates greater genetic drift in
East Asians than in Europeans. Nature Genetics, 39, 1251-5 (2007). ( Supplementary
In the News
NIH/DHHS/NHGRI U01-HG005715-01 (with PI: Carlos D. Bustamante). Population structure, admixture and selection across the 1000 Genomes data set
Sloan Research Fellowship, Alfred P. Sloan Foundation
Robert N. Noyce endowed chair
New Scholar Award in Aging, The Ellison Medical Foundation
Fall 2011: team-taught BTRY 6700: Applied Bioinformatics and Systems Biology
Spring 2012: BTRY 6820/4820 - Statistical Genomics: Coalescent Theory and Human Population Genomics
Spring 2012: BTRY 6890 - Topics in Population Genetics and Genomics
Spring 2013: BTRY 6820/4820 - Statistical Genomics: Coalescent Theory and Human Population Genomics
Spring 2013: BTRY 6890 - Topics in Population Genetics and Genomics
Colleagues and Collaborators
102C Weill Hall
Office hours: Thursdays, 3-4pm
Tel: (607) 254-1328
Fax: (607) 255-2323
To prospective graduate students: please consider any of the following graduate fields
Computational Biology and Medicine
Genetics and Development
Last update: Mar 2013
"... cause if we cease to ask,
we will cease to grow
if we don't go far,
we will soon fall. "
( Mookie D., translated from Hebrew)